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Magnolia officinalis Rehder & E.H. Wilson

Nomenclature

SCN: magnolia
PN: hou po (bark, root bark)
Part: bark, root bark

Classifications

Safety: 2b
Interaction: A

Quick Reference Summary

Contraindications

Not for use in pregnancy except under the supervision of a qualified healthcare practitioner (Bensky et al. 2004; Chen and Chen 2004).

Other Precautions

None known.

Drug and Supplement Interactions

None known.

Editors’ Note

Magnolia bark contains trace amounts of the alkaloids magnocurarine and tubocurarine (Huang 1993). Tubocurarine has also been isolated from curare, the arrow poison used by indigenous hunters of South America that can produce death by asphyxiation when administered intravenously (Blubaugh and Linegar 1948). Intravenous use of magnolia bark is noted as exhibiting some curare-like effects, though the herb is considered generally safe for oral use (Bensky and Gamble 1993), and curare itself has long been recognized as innocuous when taken orally (Blubaugh and Linegar 1948).

Adverse Events and Side Effects

None known.

Pharmacological Considerations

Although compounds from magnolia bark have demonstrated anticoagulant activity in vitro (Teng et al. 1988), animal studies indicated no effects of magnolia bark extract on coagulation (Liu et al. 2007).

Pregnancy and Lactation

Reference texts on traditional Chinese medicine indicate that magnolia bark and root bark should be used with caution in pregnancy (Bensky et al. 2004; Chen and Chen 2004). Based on this information, use during pregnancy is not recommended except under the supervision of a qualified healthcare practitioner.

No information on the safety of magnolia bark or root bark in lactation was identified. While this review did not identify any concerns for use while nursing, safety has not been conclusively established.

Food Use


Review Details

  • I. Drug and Supplement Interactions

    Clinical Trials of Drug or Supplement Interactions

    No clinical trials of drug or supplement interactions were identified.

    Case Reports of Suspected Drug or Supplement Interactions

    No case reports of suspected drug or supplement interactions were identified.

    Animal Trials of Drug or Supplement Interactions

    An increase in anxiolytic activity was observed in mice administered 0.2 mg/kg of the compound honokiol with diazepam as compared to diazepam alone (Maruyama and Kuribara 2000).

  • II. Adverse Events

    Case Reports of Adverse Events

    No case reports of adverse events were identified.

  • III. Pharmacology and Pharmacokinetics

    Human Pharmacological Studies

    No relevant human pharmacological studies were identified.

    Animal Pharmacological Studies

    No effects on coagulation were observed in rats fed diets containing up to 480 mg/kg of magnolia bark extract daily for 21 days or up to 240 mg/kg for 90 days (Liu et al. 2007).

    In Vitro Pharmacological Studies

    No estrogenic activity of an ethanol extract of magnolia bark was observed in a yeast assay system with human estrogen receptors (Shin et al. 2001).

    The compounds magnolol and honokiol inhibited aggregation and ATP release of rabbit platelet-rich plasma induced by collagen and arachidonic acid without affecting that induced by ADP, platelet-activating factor (PAF), or thrombin. Aggregation of washed platelets was more markedly inhibited than that of platelet-rich plasma, while the aggregation of whole blood was least affected by both inhibitors (Teng et al. 1988).

  • IV. Pregnancy and Lactation

    Reference texts on traditional Chinese medicine indicate that magnolia bark and root bark should be used with caution in pregnancy (Bensky et al. 2004; Chen and Chen 2004).

    No information on the safety of magnolia bark and root bark in lactation was identified. While this review did not identify any concerns for use while nursing, safety has not been conclusively established.

  • V. Toxicity Studies

    Acute Toxicity

    The LD50 values of a magnolia bark decoction are 6.12 g/kg after intraperitoneal administration in mice, 4.25 g/kg after intravenous administration in cats, and could not be determined at doses up to 60 g/kg after oral administration in mice (Chen and Chen 2004).

    Short-Term Toxicity

    In rats fed diets containing 0, 60, 120, 240, or 480 mg/kg of magnolia bark extract daily for 21 days, no treatment-related effects in clinical observations, macroscopic or microscopic findings, or hematology, clinical chemistry, urinalysis, or organ weight measurements were observed, and there were no deaths or significant differences in body weight and weight gain (Liu et al. 2007).

    Subchronic Toxicity

    In rats fed diets containing 0, 60, 120, or 240 mg/kg of magnolia bark extract daily for 90 days, no mortality, ophthalmic abnormalities, or treatment-related changes in clinical observations, hematology, coagulation, organ weight measurements, or macroscopic or microscopic evaluations were found (Liu et al. 2007).

    Genotoxicity

    In a bacterial reverse mutation assay and an in vivo micronucleus test, no genotoxic activity of magnolia bark extract was observed (Li et al. 2007).

    No genotoxic activity of magnolia bark extract was observed in chromosomal aberration assays with Chinese hamster ovary cells and Chinese hamster lung tissue (Zhang et al. 2008).

  • Literature Cited

    Bensky, D., and A. Gample. 1993. Chinese herbal medicine: Materia medica. 2nd ed. Seattle: Eastland Press.

    Bensky, D., S. Clavey, and E. Stöger. 2004. Chinese herbal medicine: Materia medica. 3rd ed. Seattle: Eastland Press.

    Blubaugh, L.V., and C.R. Linegar. 1948. Curare and modern medicine. Econ. Bot. 2(1):73-82.

    Chen, J.K., and T.T. Chen. 2004. Chinese medical herbology and pharmacology. City of Industry, CA: Art of Medicine Press.

    Huang, K.C. 1993. The pharmacology of Chinese herbs. Boca Raton, FL: CRC Press.

    Li, N., Y. Song, W. Zhang, et al. 2007. Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract. Reg. Toxicol. Pharmacol. 49(3):154-159.

    Liu, Z., X. Zhang, W. Cui, et al. 2007. Evaluation of short-term and subchronic toxicity of magnolia bark extract in rats. Reg. Toxicol. Pharmacol. 49(3):160-171.

    Maruyama, Y., and H. Kuribara. 2000. Overview of the pharmacological features of honokiol. CNS Drug Rev. 6(1):35-44.

    Shin, T.Y., D.K. Kim, B.S. Chae, and E.J. Lee. 2001. Antiallergic action of Magnolia officinalis on immediate hypersensitivity reaction. Arch. Pharmacol. Res. 24(3):249-255.

    Teng, C.M., C.C. Chen, F.N. Ko, et al. 1988. Two antiplatelet agents from Magnolia officinalis. Thromb. Res. 50(6):757-765.

    Zhang, B., T. Maniatis, Y. Song, et al. 2008. Evaluation of magnolia bark extract in chromosomal aberration assays. Mutat. Res. 654(2):133-137.

Most Recent Revision

June 18, 2014